• Drop ship requests

    Dropship accounts can be set up, however, these kits are sent standard mail, which can take up to 2 weeks for delivery. The other option would BE to keep an small inventory on hand at your office. These kits – a minimum order of 5 kits – will be sent priority mail. Priority mail shipments include a tracking number and usually arrive at the doctor’s office within 3 -5 business days from being shipped. Lastly, there is always the option to pay for RUSH shipping via UPS. UPS rush shipping kit requests must be called into the office and cannot be processed online.
  • How do I ship my sample?

    All samples must be shipped according to the instructions included in the complementary sample collection kits sent upon request. All materials necessary for shipping (i.e. return label, priority box, biohazard bags, etc.) are included in each sample collection kit. Please note that if you prefer to use your own shipping materials all biological samples must be triple contained, meaning they must be placed in the nitrogen gas filled tube, which is placed in a larger tube or baggie, which is finally placed in the biohazard bag.
  • How do I ship samples internationally?

    We gladly accept samples from anywhere in the world. The protocol for sample collection remains the same.


  • What type of payment do you accept?

    We accept Visa, Mastercard, Discover, and American Express. We also accept personal checks and money orders made out to DNA Connexions. Please be aware that samples are not be processed until payment is received in full and the RUSH option is not available for samples paid with a personal check.
  • Can I be billed for the samples I send at the end of each month?

    This is a payment option available to medical providers only. We do offer credit accounts for medical providers that are approved after a simple application process. For more details on a credit account please contact the office at
  • If I do multiple tests, can I receive a discount?

    The fee per test is absolute. Every sample sent in IS PROCESSED AND run separately using time and materials for each. You can, however, combine multiple samples together and run AS one test WITH THE UNDERSTANDING THAT WITH COMBINED SAMPLES YOU WILL RECEIVE ONLY ONE REPORT ENCOMPASSING ALL MICROBES IDENTIFIED FOR ALL SAMPLES INCLUDED.
  • Does DNA CONNEXIONS offer free testing for research?

    DNA CONNEXIONS is a For-Profit research lab and does not offer free. When developing new tests, we MAY OFFER tests for a promotional fee for a limited time.


  • What tests do we provide?

    Full View Test, Lyme Test, ApoE Test, AND Gluten Intolerance. For full descriptions of these tests, please click the specific test links.
  • What techniques are used in testing?

    DNA CONNEXIONS UTILIZES STATE OF THE molecular GENETIC techniques such as DNA EXTRACTION TECHNIQUES FROM A VARIETY OF BIOLOGICAL SPECIMENS, PCR, Reverse transcriptase-PCR, and gel electrophoresis to identify the specific gene associated with each MICROBE.

Sensitivity and Specificity of Our Tests

  • What tests do we provide?

    Our testing UTILIZES PCR (polymerase chain reaction) which is essentially a Xerox machine for genes. In about 2 hours, we can turn 1 copy of a gene into over a billion. This many copies of DNA, if greater than 200 base pairs, are easily detectable in an agarose gel stained with ethidium bromide. This means that we can detect the presence of the FOREIGN DNA from AS LITTLE AS one microbe.

    How PCR works is elegantly demonstrated in this animation from the Dolan DNA Learning center: View page

    The use of HIGHLY SPECIFIC DNA primers, which are sequences of DNA at the beginning and end of a gene (or DNA fragment) determines the specificity of our test. Because A binds to T and G binds to C and vice versa, a primer of 20 bases would have a specificity of 420 power or 1 trillion, 99 billion, 511 million, 627 thousand, 776. This value is greater than any known genome. To assure that this is ACCURATE, we use a program called B.L.A.S.T. from (Genbank) to test our primers to make certain that they are specific for only the microbe we are testing FOR.

    PCR Electrophoresis Gel


  • Can the microbes present on my results be treated with ozone?

    There are CURRENTLY 21 obligate anaerobes (poisoned by oxygen) on our Full View test that can be treated with ozone.

    Obligate anaerobes currently tested for by DNA CONNEXIONS :
    Bacteroides fragilis - Clostridium botulinum - Clostridium difficile - Clostridium perfringens - Clostridium tetani - Filifactor alocis - Fusobacterium nucleatum ss vincentii - Fusobacterium nucleatum ss nucleatum - Fusobacterium nucleatum ss Polymorphum - Leptotrichia buccalis - Peptostreptococcus micros - Porphyromonas endodontalis - Porphyromonas gingivalis - Prevotella denticola - Prevotella intermedia - Prevotella melaninogenica - Prevotella nigrescens - Propionibacterium acnes - Tannerella forsythia - Treponema denticola - Veillonella parvula
  • I have MICROBES on my test results that are not on this list. How do I treat those?

    DNA CONNEXIONS provides A COMPREHENSIVE REPORT of all microbes DETECTED IN YOUR SAMPLE INCLUDING THE GENERAL DESCRIPTION OF THE MICROBE, SYMPTOMS OF INFECTION AND THE CURRENT CDC RECOMMENDED TREATMENT OPTIONS. As DNA CONNEXIONS is not a diagnostic lab, we recommend REVIEWING your test results with a qualified healthcare provider to discuss your personal health and plan of action to wellness.


  • What types of samples may be used for testing?

    Full View Test: you may SUBMIT ANY OF THE FOLLOWING: TEETH (including root canal teeth), blood, TISSUE,, cavitationS, bone GRAFTS, IMPLANTS, FLOSS, SWABS OR SALINE rinse. All kits provided by DNA Connexions contain all the necessary collection materials and comprehensive collection instructions.
    Lyme Test: best results are realized with urine, however, we may use any sample from the mouth as well.
    Gluten Intolerance Test: saline rinse or buccal swabs.
    ApoE Test: saline rinse or buccal swabs.
  • How do I collect my sample?

    All collection kits include all necessary instructions and materials; Simply place the sample in the provided tubes and send the sample back to us according to the instructions provided.
  • How do I preserve my sample?

    All collection kits include nitrogen gas in the provided tubes, which preserves the DNA of the sample by inhibiting the action of DNAses. Please do not place the sample in formaldehyde, formalin, water or saline.
  • How do I store my sample?

    We recommend storing the sample (EXCEPT LYME TEST SAMPLES) in the freezer until shipping; The nitrogen gas will prevent degradation during shipping once the sample is no longer in the freezer
  • Can I collect a sample by myself?

    Yes, absolutely. We encourage patients to collect and send samples themselves. Simply follow the instructions included in each sample collection kit. Examples of these forms can also be found be found on our website.
  • How do I collect a Lyme Test sample?

    We recommend urine be sent for this test. Urine should never be stored in the freezer. The urine sample should be collected at any time except for first morning urination as it contains too much molecular debris to achieve accurate results. It is best to exercise vigorously before collection.
  • How long does the nitrogen gas used in sample collection kits last?

    Three months; an expiration date can be found stamped on each nitrogen filled tube.


  • What is the meaning of “NSA” on my Lyme report?

    Our PCR is very specific but what we sometimes achieve are amplification products not of the expected size.  As we know Lyme is a multi system, multi tissue, and multi organ disease and within an individual there can exist separately evolving populations which perpetuate individual mutations (insertions, deletions, etc.).  As we utilize urine as our preferred method of sampling we are trying to achieve a sample which is representative of all of the populations within an individual.  While the amplification product is not of the expected size, DNA sequence analysis has confirmed the species specific sequence identity of the amplification products.  Once a non-predicted size is seen over a population (over 10 individuals) and the sequencing identification is confirmed with over 90% sequence alignment, the NSA designation is removed.
  • What exactly does the notation on the bottom of your report mean when it says “Species specific target microbial DNA was detected but amplification product was not of expected size?

    All of our samples go through three stages of quality control both before and during the Lyme Panel assay.  Our results are confirmed with DNA sequence analysis by a third party company.  DNA Sequence alignments must exceed greater than 99% sequence identity in order to qualify as a ‘positive’ result.  In addition, every patient sample, every positive control, and every negative control are run in duplicate for each run of the Lyme Panel for consensus.  We also run ‘pools’ of ‘known positives’ and ‘known negatives’ on a regular basis for further validation.
  • What is your negative findings rate?

    Last year, 2016, our net negative rate was about 9%.  That includes all 14 microbes when there is NONE detected.  Initially people think that that is a very low rate, BUT our ‘population’ of samples needs to be considered at this point.  It is not the everyday person who requests this test.  The majority are under the care of a Lyme literate physician, and believe they are suffering from at least one, if not more, tick borne infections.

    Our panel consists of 14 DNA target regions and even 1 positive result is counted as a positive test.  Our ‘net negative rate’ is consistently about 9%.  Meaning that 91% of the samples we receive amplify at least one target region on the Lyme Panel.  Additionally, not every positive panel amplifies any of the 4 unique genetic regions of Borrelia burgdorferi we target.  In those cases, the results are positive for one or more co-infections, but not the causative agent of Lyme disease.

    Now that we are implementing the new quality control, as of Feb this year, that the net negative rate will  be even lower.  That said, we are only able to detect what is in the sample provided.  We know burgdorferi is an elusive organism, and a negative test could be the result of sampling.  Heat killed Borrelia dilution studies has shown that we can detect as few 10 organisms in a sample.
  • How long until I receive my results?

    Our average turnaround time for all test results is 2-3 weeks.* Depending on the amount of samples waiting to be processed at the time of receipt of your sample. In addition, every sample must pass strict quality control guidelines which may delay the reporting process. A RUSH fee is an option to receive results within 5-7 business days from receipt of your sample. These are our TYPICAL reporting estimates and not a guarantee of reporting times or dates. Please note that samples are not tested until payment is received. *If you need your results by a specific date, please contact the office to facilitate shipping and possible rush fees to ensure there is enough time for us to receive the sample, complete the testing and have the reports available when you need them.*
  • How do I receive my results?

    Results are sent both via e-mail and a hard copy via mail to the prescribing physician.
  • What do I do now that I have my results?

    We recommend you review your results with a qualified healthcare practitioner to discuss treatment options.

Lyme Panel

  • How is DNA Connexions Lyme Panel different than other tests for Lyme?

    Our is a direct test, looking for the DNA of the organism itself.  Western Blot is indirect, detection of antibodies, if being produced.  Our booklet of references shows previous research on PCR, comparison to antibody testing, as well as studies showing the urinary tract is a site of spirochetal persistence.

    After DNA purification we run each sample in a Quality Control step.  What this shows is: the purification process worked and there is amplifiable, not degraded, DNA.  This also significantly lessens our false negative rate, as we have verified the presence of amplifiable DNA. 
  • What does your Lyme Panel test for?

    The test uses primers which are specific for the genes of the Borrelia burgdorferi flagella, outer surface protein A, B and C. A positive test result for any of these 4 genes indicates the presence of the Lyme organism. Testing of common Lyme co-infectors (other tick-transmitted organisms) indicates likely infection with the Lyme spirochete as well. DNA Connexions currently tests for Babesia divergens, Babesia duncani, Babesia microti, Bartonella bacilliformis, Bartonella henselae, Bartonella quintana, Borrelia miyamotoi, Borrelia recurrentis, and Ehrlichia chaffeensis and Anaplasma phagocytophilum.
  • How does the DNA Connexions Lyme test differ from the Western Blot test?

    The Lyme test offered by DNA Connexions is a PCR (DNA based) test, not an antibody or Western Blot test. The western blot is a widely used analytical technique used to detect specific proteins in a sample of tissue homogenate or extract. It uses gel electrophoresis to separate native proteins by 3-D structure or denatured proteins by the size of the polypeptide. The proteins are then transferred to a membrane (typically nitrocellulose or PVDF), where they are stained with antibodies specific to the target protein. The gel electrophoresis step is included in western blot analysis to resolve the issue of the cross-reactivity of antibodies. The problem with the western blot is that it is protein antibody based. Proteins denature under a variety of conditions, making it unrecognizable to the antibody specific for that protein. Antibodies, even monoclonal antibodies have a lower specificity for their target than primers in a PCR mix. Another issue with the antibody assay is that it is a measure of your immune system’s response to the presence of the spirochete. As the disease progresses and changes so to does your immune response, making detection at any stage of the disease difficult. PCR utilizes amplification of the microbial DNA itself for its target. One copy is turned into a billion copies in 2 hours. A positive result indicated the presence of DNA from the disease causing agent (Borrelia burgdorferi and/or other co-infectors), while a negative result indicates the absence of detectable B. burgdorferi and/or other co-infectors in the specimen.